Antibodies for
Immunohistochemistry
Somatostatin (Polyclonal)
Rabbit Polyclonal Antibody
Cat. No. Description
Volume
45259 IMPATH Somatostatin RTU R (Poly)
50 Tests
44386 Somatostatin RTU R (Poly)
7 ml Ready To Use
44791 Somatostatin 0,1 R (Poly)
100 µl liquid Concentrated
44792 Somatostatin 1 R (Poly)
1 ml liquid Concentrated
Product Specifications
Designation
IVD
Reactivity
Paraffin
Visualization
Cytoplasmic
Control
Pancreas
Stability
Up to 36 mo. at 2-8°C
Manual Protocol*
• Pretreatment: Heat Induced Epitope
Retrieval (HIER)
• Primary Antibody Incubation Time:
10-30min @ 25-37°C
• 2-step polymer detection
*Please refer to product insert for complete protocol.
ImPath Protocol*
• Dewax: Dewax Solution 2 (DS2)
• Pretreatment: Retrieval Solution pH 9.0
(TR1) 32min @ 98-103°C
• Primary Antibody Incubation Time:
10-90min @ 25-37°C
• HRP Polymer (Universal) or AP Polymer
(Universal) for 12 min
*Please refer to product insert for complete protocol.
Product Description
Somatostatin (also known as growth hormone inhibiting hormone (GHIH) or somatotropin release-inhibiting factor (SRIF)) is a peptide hormone
widely distributed throughout the body and is an important regulator of endocrine and nervous system function. Somatostatin can also be found
in gastrointestinal and bronchopulmonary endocrine cells, thymic endocrine cells, and thyroid C-cells. Somatostatin suppresses gastric acid
secretion, gallbladder contractions, and pancreatic enzyme secretion. This antibody specifically stains the D-cells of the pancreatic islets of
Langerhans and tumors arising from these cells. It recognizes somatostatin-containing cells in pancreatic tumors, islet cell hyperplasia, and islet
cells originating in pancreatic ductules.
Pancreas
Somato-
statin
Synapto-
physin
Chromo-
granin A Gastrin CD56 β-Catenin CK 19 CA19-9 E-cadherin CD10
Ductal Adenocarcinoma
-
-
-
-
-
+/-
+
+
+/-
+/-
Neuroendocrine Tumor
+/-
+
+
+/-
+
+
+/-
+/-
-
-
Solid Pseudopapillary
Tumor
+
-
-
+
+
-
-
+(nuclear)
+
Acinic Cell Carcinoma
-
-
-
-
+
+
-/+
+
+/-
Pancreatoblastoma
-
-
+
-
+
+
-
-
-
-
Normal Pancreas
+
+
+
-
-
+
-
-
-
-
Reference
1. Krejs GJ, et al. N Eng J Med. 1979; 301:285-292.
2. Somers G, et al. Gastroenterology. 1983; 85:1192-1198.
3. Erlandsen SL. Williams and Wilkins, Baltimore. 1980. pp140-155.
4. Friesen SR. N Eng J Med. 1982; 306:580-590.
5. Tzaneva MA. Acta Histochem. 2003; 105(2):191-201.
6. Quartu M, et al. J Chem Neuroanat. 1993 Mar-Apr; 6(2):79-99.
7. Fried G, et al. Cancer. 1994 Jul 1; 74(1):142-51.
8. Waldum HL, et al. Cancer Detect Prev. 1994; 18(6):431-6.
9. Kanavaros P, et al. Histol Histopathol. 1990 Jul; 593):325-8.
10. Chejfec G, et al. Ultrastruct Pathol. 1992 Sep-Oct; 16(5):537-45.
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