Antibodies for
Immunohistochemistry
Renal Cell Carcinoma (PN-15)
Mouse Monoclonal Antibody
Cat. No. Description
Volume
44382 Renal Cell Carcinoma RTU M (PN-15)
7 ml Ready To Use
44783 Renal Cell Carcinoma 0,1 M (PN-15)
100 µl liquid Concentrated
44784 Renal Cell Carcinoma 1 M (PN-15)
1 ml liquid Concentrated
Product Specifications
Designation
IVD
Reactivity
Paraffin
Visualization
Cytoplasmic, Membranous
Control
Renal Cell Carcinoma
Stability
Up to 36 mo. at 2-8°C
Isotype
IgG
1
/k
Manual Protocol*
• Pretreatment: Heat Induced Epitope
Retrieval (HIER)
• Primary Antibody Incubation Time:
10-30min @ 25-37°C
• 2-step polymer detection
*Please refer to product insert for complete protocol.
Product Description
Anti-renal cell carcinoma (RCC) recognizes a 200 kD glycoprotein localized in the brush border of the proximal renal tubule.
This antibody immunoreacts with approximately 90%of primary renal cell carcinomas and approximately 85%of metastatic renal cell carcinomas.
Therefore, anti-RCC is a reliable tool for differentiating primary or metastatic renal cell carcinoma from non-renal tumors. It may be utilized as a
marker for the differential diagnosis of eosinophilic renal tumors-granular variant of renal cell carcinoma, chromophobe renal cell carcinoma, and
oncocytoma. Other tumors that may react with this antibody are parathyroid adenoma and an occasional breast carcinoma. Nephroblastoma,
oncocytoma, mesoblastic nephroma, transitional cell carcinoma, and angiomyolipoma are not labeled with this antibody.
Kidney: Renal Epithelial Tumors
RCC
CD10
PAX-2
Vimentin Ksp-cadherin Parvalbumin CD117
Ep-CAM
Clear Cell RCC
+
+
+
+
-
-
-
-
Chromophobe RCC
-/+
-/+
+
-
+
+
+
+
Oncocytoma
-
+/-
+
-
+/-
+
+
-
Reference
1. Avery AK, et al. Am J Surg Pathol. 2000; 24(2):203-210.
2. McGregor DK, et al. Am J Surg Pathol. 2001; 25(12):1485-1492.
3. Gokden N, et al. Appl Immunohistochem Mol Morphol. 2003 Jun; 11(2):116-9.
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