Advanced Solutions
for Advanced Pathology
CD68 (Kp-1)
Mouse Monoclonal Antibody
Cat. No. Description
Volume
45187 IMPATH CD68 RTU M (Kp-1)
50 Tests
44249 CD68 RTU M (KP-1)
7 ml Ready To Use
44519 CD68 0,1 M (KP-1)
100 µl liquid Concentrated
44520 CD68 1 M (KP-1)
1 ml liquid Concentrated
Product Specifications
Designation
IVD
Reactivity
Paraffin
Visualization
Cytoplasmic, Membranous
Control
Tonsil
Stability
Up to 36 mo. at 2-8°C
Isotype
IgG
1
/k
Manual Protocol*
• Pretreatment: Heat Induced Epitope
Retrieval (HIER)
• Primary Antibody Incubation Time:
10-30min @ 25-37°C
• 2-step polymer detection
*Please refer to product insert for complete protocol.
ImPath Protocol*
• Dewax: Dewax Solution 2 (DS2)
• Pretreatment: Retrieval Solution pH 9.0
(TR1) 32min @ 98-103°C
• Primary Antibody Incubation Time:
10-90min @ 25-37°C
• HRP Polymer (Universal) or AP Polymer
(Universal) for 12 min
*Please refer to product insert for complete protocol.
Product Description
Anti-CD68 marks cells of monocyte/macrophage lineage. This antibody is capable of staining monocytes, Kupffer cells, osteoclasts, granulocytes
and their precursors; lymphomas are negative or show few granules. This antibody may be useful for the identification of myelomonocytic and
histiocytic tumors. Since this detects a formalin-resistant epitope that may be associated with lysosomal granules, other lysosome-rich cells
may also stain.
Acute Myeloid Leukemia
CD68
MPO Factor VIII
CD61 Lysozyme BOB.1 Oct-2 Glyco-
phorin A CD34 CD138
Acute Myeloid, M0
-
-
-
-
+
-
-
-
+
+
Acute Myeloid, M1&2
+
+
-
-
+
-
+
+
Promyelocytic, M3
-
+
-
-
-
+
+
-
-
Myelomonocytic, M4
+
+
-
-
+
-
+
-
+
Monoblastic, M5
+
+
-
-
+
-
+
-
-/+
Acute Erythroid, M6
-
+
-
-
-
-
+
-/+
+
Megakaryoblastic, M7
-
-
+
+
+/-
-
-
-
-
Lymph Node
CD68
S-100
CD1a
Lysozyme
CD21/CD35
PD-1
Reactive Histiocytosis
+
-
-
+
-
-
Langerhans Histiocytosis
+
+
+
+
-
-
Sinus Histiocytosis with
Massive Lymphadenopathy
+
+
-
+
-
-
Follicular Dendritic Cell
Sarcoma
-
-
+/-
-
+
-
Dermatopathic
Lymphadenitis
-
+
+
+
-
-
Histiocytic Neoplasia
CD68
CD45
CD4
Lysozyme
CD163 Factor XIIIa
CD20
CD3
Histiocytic Neoplasia
+
+
+
+
+
+
-
-
Reference
1. Facchetti F, et al. Histopathology. 1991; 19:141-5.
2. Ruco LP, et al. Am J Clin Pathol. 1989; 92:273-9.
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