Antibodies for
Immunohistochemistry
CD57 (NK-1)
Mouse Monoclonal Antibody
Cat. No. Description
Volume
45134 IMPATH CD57 RTU M (NK-1)
50 Tests
44246 CD57 RTU M (NK-1)
7 ml Ready To Use
44513 CD57 0,1 M (NK-1)
100 µl liquid Concentrated
44514 CD57 1 M (NK-1)
1 ml liquid Concentrated
Product Specifications
Designation
IVD
Reactivity
Paraffin
Visualization
Membranous
Control
Tonsil
Stability
Up to 36 mo. at 2-8°C
Isotype
IgM/K
Manual Protocol*
• Pretreatment: Heat Induced Epitope
Retrieval (HIER)
• Primary Antibody Incubation Time:
10-30min @ 25-37°C
• 2-step polymer detection
*Please refer to product insert for complete protocol.
ImPath Protocol*
• Dewax: Dewax Solution 2 (DS2)
• Pretreatment: Retrieval Solution pH 9.0
(TR1) 32min @ 98-103°C
• Primary Antibody Incubation Time:
10-90min @ 25-37°C
• HRP Polymer (Universal) or AP 2-step
Polymer (Universal) for 12 min
*Please refer to product insert for complete protocol.
Product Description
Anti-CD57 (anti-NK-1) marks a subset of lymphocytes known as natural killer (NK) cells. Follicular center cell lymphomas often contain many
NK cells within the neoplastic follicles. Anti-CD57 also stains neuroendocrine cells and their derived tumors, including carcinoid tumor and
medulloblastoma. Anti-CD57 can also be useful in separating type B3 thymoma from thymic carcinoma when combined with a panel that
includes antibodies against GLUT1, CD5, and CEA.
Thymus
CD57
CK 5&6 Mesothelin MOC-31
CEA
CD117
CD5
GLUT1
Thymic Carcinoma
+
+
-
-/+
+
-
+
+
Thymoma
+/-
-/+
+
+
-
+
-
-
Neuroid Skin Lesions
CD57
S-100
Myelin BP
GFAP
Neuroma
+
+
+
-
Neurotised Nevi
-
+
-
-
Neurofibroma
+
+
+
-
T-cell Lymphomas
CD57
CD2
CD3
CD4
CD5
CD7
CD25 CD45RO Perforin Granzyme
B
NK-Type
+/-
+
+
-
-
+
+
+
-
+
Peripheral
-
+
+
+
+
-
+
+
-
-
Small, Round Blue Cell Tumors
CD57
PGP 9.5 SM Actin CK Cocktail
CD99
FLI-1
WT1
Vimentin
INI-1
Neuroblastoma
+
+
-
-
-
-
-
+
+
Embryonal Carcinoma
+
+
-
+
-
-
-
-
+
PNET/ES
+
+
-
-/+
+
+
-
+
+
DSRCT
+/-
-
-
+
-
+
+
+
+
Medulloblastoma
+
-
-
-
-
-
+
Reference
1. Lanier LL, et al. Journ of Immun. 1983; 131(4):1789-1796.
2. Ritchie AW, James K, Micklem HS. Clin and Exp Imm. 1983; 51(3):439-447.
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