Antibodies for
Immunohistochemistry
Cytokeratin (OSCAR)
Mouse Monoclonal Antibody
Cat. No. Description
Volume
45299 IMPATH Cytokeratin RTU M (OSCAR)
50 Tests
44265 Cytokeratin RTU M (OSCAR)
7 ml Ready To Use
44551 Cytokeratin 0,1 M (OSCAR)
100 µl liquid Concentrated
44552 Cytokeratin 1 M (OSCAR)
1 ml liquid Concentrated
Product Specifications
Designation
IVD
Reactivity
Paraffin
Visualization
Cytoplasmic
Control
Prostate
Stability
Up to 36 mo. at 2-8°C
Isotype
IgG
2a
Manual Protocol*
• Pretreatment: Heat Induced Epitope
Retrieval (HIER)
• Primary Antibody Incubation Time:
10-30min @ 25-37°C
• 2-step polymer detection
*Please refer to product insert for complete protocol.
ImPath Protocol*
• Dewax: Dewax Solution 2 (DS2)
• Pretreatment: Retrieval Solution pH 9.0
(TR1) 32min @ 98-103°C
• Primary Antibody Incubation Time:
10-90min @ 25-37°C
• HRP Polymer (Universal) or AP Polymer
(Universal) for 12 min
*Please refer to product insert for complete protocol.
Product Description
Anti-cytokeratin (OSCAR) is well-suited to distinguish epithelial carcinoma from non-epithelial malignancies and is used to aid epithelial tumor
classification. This antibody has been used to characterize the source of various neoplasms and to study the distribution of keratin containing
cells in epithelia during normal development and during the development of epithelial neoplasms. This antibody stains cytokeratins present in
normal and abnormal human tissues and has shown high sensitivity in the recognition of epithelial cells and carcinomas.
Carcinomas
CK,
OSCAR CK 7
CK 20
CK 5
p63
TTF-1 GCDFP-15 pCEA Hep-Par1 RCC
Hepatocellular Carcinoma
-
-
-
-
-
+
(cytoplasmic)
-
+
+
-
Renal Cell Carcinoma
+
-
-
-
-
-
-
-
-
+
Bladder Carcinoma
+
+
+
-
-
-
-
+
-
-
Salivary Gland Carcinoma
+
+
-
+
+
+
+
-
-
Thyroid Carcinoma
+
+
-
-
-
+
-
-
-
-
Spindle Cell Carcinoma
+
-
-
-
-
-
-
-
-
Breast Carcinoma
+
+
-
-
-
-
+
-
-
-
Lung Adenocarcinoma
+
+
-
-
-
+
-
+
-
-
Colorectal Adenocarcinoma
+
-
+
-
-
-
-
+
-
-
Prostate Adenocarcinoma
+
-
-
-
+
-
-
-
-
-
Transitional Cell Carcinoma
+
+
+
+
+
-
-
-
-
-
Ovarian Carcinoma
+
+
-
+
-
-
-
-
-
-
Cervical Carcinoma
+
+
-
-
-
-
-
+
-
-
Sweat Gland Carcinoma
+
+
-
+
+
+
+
-
-
Pancreatic Carcinoma
+
+
-
-
-
-
-
+
-
-
Gastric Carcinoma
+
+
-
-
-
-
-
+
-
-
Squamous Cell Carcinoma
+
-
-
+
+
-
-
-
-
-
Endometrial
Adenocarcinoma
+
+
-
-
-
-
-
-
Reference
1. Battifora H. Am J Surg Pathol. 1988; 12:24.
2. Gown AM, et al. Am J Clin Pathol. 1985; 84:413.
3. Knapp AC, et al. Cell. 1989; 59:67-79.
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