Advanced Solutions
for Advanced Pathology
Ep-CAM/Epithelial Specific Antigen (MOC-31)
Mouse Monoclonal Antibody
Cat. No. Description
Volume
44283 EP-CAM RTU M (MOC-31)
7 ml Ready To Use
44588 EP-CAM 0,1 M (MOC-31)
100 µl liquid Concentrated
44589 EP-CAM 1 M (MOC-31)
1 ml liquid Concentrated
Product Specifications
Designation
IVD
Reactivity
Paraffin
Visualization
Cytoplasmic
Control
Colon Adenocarcinoma
Stability
Up to 36 mo. at 2-8°C
Isotype
IgG
1
/k
Manual Protocol*
• Pretreatment: Heat Induced Epitope
Retrieval (HIER)
• Primary Antibody Incubation Time:
10-30min @ 25-37°C
• 2-step polymer detection
*Please refer to product insert for complete protocol.
Product Description
Anti-MOC-31 reacts with a transmembrane glycoprotein present on most glandular epithelium and tumors originating from such epithelium.
This antibody has been used to distinguish adenocarcinoma from mesothelioma and hepatocellular carcinoma. This antibody is also useful in
distinguishing serous carcinomas of the ovary from mesothelioma.
Colon vs. Ovarian Carcinoma
MOC-31 CK 7
CK 20
CEA CDX-2
Villin CA19-9 WT1 CA-125 CK 5
Ovarian Carcinoma, Serous
+
+
-
+
-
+
+
+
+
-
Ovarian Carcinoma,
Mucinous
+
+
-
-
+
+
+
-
-
Ovarian Endometrioid
Carcinoma
+
+
-
-
-
+/-
+
+
-
Colon Carcinoma
+
-
+
+
+
+
+
-
-
-
Kidney: Renal Epithelial Tumors
MOC-31
RCC
CD10
PAX-2
Vimentin Ksp-cadherin Parvalbumin CD117
Clear Cell RCC
-
+
+
+
+
-
-
-
Chromophobe RCC
+
-/+
-/+
+
-
+
+
+
Oncocytoma
-
-
+/-
+
-
+/-
+
+
Skin: Basal vs. Squamous Cell Carcinoma
MOC-31
CK Cocktail
EMA
BCL2
Basal Cell Carcinoma
+/-
+
-
+
Squamous Cell Carcinoma
-/+
+
+
-
Pleura: Adenocarcinoma vs. Mesothelioma
MOC-31 Calretinin CK 5&6 D2-40 HBME-1 Caldesmon CEA TAG-72 E-cadherin TTF-1
Adenocarcinoma
+
-
-
-
-
-
+
+
+
+
Mesothelioma
-
+
+
+
+
+
-
-
-
-
Reference
1. Kakar S, et al. Arch Pathol Lab Med. 2007 Nov; 131(11):1648-54. Review.
2. King JE, et al. Histopathology. 2006 Feb; 48(3):223-32. Review.
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