Advanced Solutions
for Advanced Pathology
Factor XIIIa (EP3372
†
)
Rabbit Monoclonal Antibody
Cat. No. Description
Volume
44287 Factor XIIIa RTU R (EP3372)
7 ml Ready To Use
44596 Factor XIIIa 0,1 R (EP3372)
100 µl liquid Concentrated
44597 Factor XIIIa 1 R (EP3372)
1 ml liquid Concentrated
Product Specifications
Designation
IVD
Reactivity
Paraffin
Visualization
Cytoplasmic
Control
Dermatofibroma
Stability
Up to 36 mo. at 2-8°C
Isotype
IgG
Manual Protocol*
• Pretreatment: Heat Induced Epitope
Retrieval (HIER)
• Primary Antibody Incubation Time:
10-30min @ 25-37°C
• 2-step polymer detection
*Please refer to product insert for complete protocol.
Product Description
Factor XIIIa is a blood proenzyme that has been identified in platelets, megakaryocytes, and fibroblast-like mesenchymal or histiocytic cells
present in the placenta, uterus, and prostate; it is also present in monocytes, macrophages, and dermal dendritic cells. Anti-factor XIIIa has
been found to be useful in differentiating between dermatofibroma (90% (+)), dermatofibrosarcoma protuberans (25%(+)), and desmoplastic
malignant melanoma (0%(+)). Anti-factor XIIIa positivity is also seen in capillary hemangioblastoma (100%(+)), hemangioendothelioma (100%(+)),
hemangiopericytoma (100%(+)), xanthogranuloma (100%(+)), xanthoma (100%(+)), hepatocellular carcinoma (93%(+)), glomus tumor (80%(+)),
and meningioma (80 % (+)).
Melanotic Lesions
Factor XIIIa S-100
HMB-45 MART-1 Tyrosinase MiTF
CD63
WT1
SOX-10
Junctional Nevus
-
+
+
+
+
+
-
+/-
Primary Melanoma
-
+
+
+
+
+
+
+
Metastatic Melanoma
-
+
+
+
+
+
+
+
+
Adrenal Cortical
-
+
-
+
-
-
-
Dermatofibroma
+
-
-
-
-
-
-
Skin: Spindle Cell Tumors
Factor XIIIa MS Actin CD10 SM Actin CD34
NGFR
CD99
A1ACT
A1AT
Atypical Fibroxanthomas
+/-
+
+
+
-
-
+
+
+
Dermatofibrosarcoma
Protuberans
-
-
+/-
-
+
+
-
-
-
Dermatofibroma Fibrous
Histiocytoma
+
-
+
-
-
-
-
-
-
Histiocytic Proliferation
Factor XIIIa
S-100
CD68
Vimentin
Lysozyme
CD1a
HAM-56
Juvenile Xanthogranuloma
+
-
+
+
+
-
+
Langerhans Cell
Histiocytosis
-
+
+
+
+
+
+
Dermatofibroma
+
-
+
+
-
-
-
Reference
1. Abenoza P, Lillemoe T. Am J Dermatopathol. 1993 Oct; 15(5):429-34.
2. Anstey A, Cerio R, et al. Am J Dermatopathol. 1994 Feb; 16(1):14-22.
3. Glusac EJ, Barr RJ, et al. Am J Surg Pathol. 1994 Jun; 18(6):583-90.
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