Antibodies for
Immunohistochemistry
Gastrin (Polyclonal)
Rabbit Polyclonal Antibody
Cat. No. Description
Volume
45143 IMPATH Gastrin RTU R (Poly)
50 Tests
44292 Gastrin RTU R (Poly)
7 ml Ready To Use
44606 Gastrin 0,1 R (Poly)
100 µl liquid Concentrated
44607 Gastrin 1 R (Poly)
1 ml liquid Concentrated
Product Specifications
Designation
IVD
Reactivity
Paraffin
Visualization
Cytoplasmic
Control
Stomach
Stability
Up to 36 mo. at 2-8°C
Manual Protocol*
• Pretreatment: Heat Induced Epitope
Retrieval (HIER)
• Primary Antibody Incubation Time:
10-30min @ 25-37°C
• 2-step polymer detection
*Please refer to product insert for complete protocol.
ImPath Protocol*
• Dewax: Dewax Solution 2 (DS2)
• Pretreatment: Retrieval Solution pH 9.0
(TR1) 32min @ 98-103°C
• Primary Antibody Incubation Time:
10-90min @ 25-37°C
• HRP Polymer (Universal) or AP Polymer
(Universal) for 12 min
*Please refer to product insert for complete protocol.
Product Description
Gastrin is a hormone whose main function is to stimulate secretion of hydrochloric acid by the gastric mucosa, which results in gastrin formation
inhibition. This hormone also acts as a mitogenic factor for gastrointestinal epithelial cells. Gastrin has two biologically active peptide forms: G34
and G17. They activate two different receptors: the CCK-1 receptor, which has low affinity for gastrin but high affinity for the related hormone
cholecystokinin (CCK), and the CCK-2 receptor, which has high affinity for both gastrin and CCK and mediates the acid-secretory as well as
the proliferative effects of gastrin. More recently, gastrin has been suggested to induce leukocyte-endothelial cell interactions and to have a
pro-inflammatory effect. Anti-gastrin stains G-cells of human antral/pyloric mucosa and cells producing gastrin or a structural gastrin analog as
is seen in stomach; no staining of other cells or tissue types has been observed. This antibody may react with sulfated and nonsulfated forms
of gastrin.
Reference
1. Kirchner T, et al. Am J Surg Path. 1987; 11:909-17.
2. Bornstein-Quevedo L, Gamboa- Dominguez A. Hum Pathol. 2001 Nov; 32(11):1252-6.
3. Herrmann ME, et al. Arch Pathol Lab Med. 2000 Jun; 124(6):832-5.
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