Advanced Solutions
for Advanced Pathology
GH (Polyclonal)
Rabbit Polyclonal Antibody
Cat. No. Description
Volume
45210 IMPATH GH RTU R (Poly)
50 Tests
44293 GH RTU R (Poly)
7 ml Ready To Use
44608 GH 0,1 R (Poly)
100 µl liquid Concentrated
44609 GH 1 R (Poly)
1 ml liquid Concentrated
Product Specifications
Designation
IVD
Reactivity
Paraffin
Visualization
Cytoplasmic
Control
Pituitary
Stability
Up to 36 mo. at 2-8°C
Manual Protocol*
• Pretreatment: Heat Induced Epitope
Retrieval (HIER)
• Primary Antibody Incubation Time:
10-30min @ 25-37°C
• 2-step polymer detection
*Please refer to product insert for complete protocol.
ImPath Protocol*
• Dewax: Dewax Solution 2 (DS2)
• Pretreatment: Retrieval Solution pH 9.0
(TR1) 32min @ 98-103°C
• Primary Antibody Incubation Time:
10-90min @ 25-37°C
• HRP Polymer (Universal) or AP Polymer
(Universal) for 12 min
*Please refer to product insert for complete protocol.
Product Description
Pituitary growth hormone (GH) plays a crucial role in stimulating and controlling the growth, metabolism and differentiation of many mammalian
cell types by modulating the synthesis of multiple mRNA species. These effects are mediated by the binding of GH to its membrane-bound
receptor, GHR, and involve a phosphorylation cascade that results in the modulation of numerous signaling pathways. GH is synthesized by
acidophilic or somatotropic cells of the anterior pituitary gland. Human growth hormone contains 191 amino acid residues with two disulfide
bridges. Anti-GH is a useful marker in classification of pituitary tumors and the study of pituitary disease (acromegaly). It reacts with GH-
producing cells. Growth hormone receptors have been found in various non-pituitary cells, including that from hepatocellular carcinoma and
various benign and malignant cutaneous lesions.
Pituitary Panel
GH
ACTH
FSH
LH
Prolactin
TSH
Pituitary
+
+
+
+
+
+
Reference
1. Fukaya T, et al. Cancer. 1980; 45:15981.
2. Kovacs K, et al. Virch Arch Pathol Anat. 1982; 395:59.
3. Cunha KS, et al. J Clin Pathol. 2003 Oct; 56(10):758-63.
4. Chopin LK, et al. Growth Horm IGF Res. 2002 Apr; 12(2):126-36.
5. Matsuno A, et al. Pathol Res Pract. 2001; 197(1):13-20.
6. Garcia-Caballero T, et al. Endocrine. 2000 Jun; 12(3):265-71.
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