Antibodies for
Immunohistochemistry
Glial Fibrillary Acidic Protein (GFAP) (EP672Y
†
)
Rabbit Monoclonal Antibody
Cat. No. Description
Volume
44294 GFAP RTU R (EP672Y)
7 ml Ready To Use
44610 GFAP 0,1 R (EP672Y)
100 µl liquid Concentrated
44611 GFAP 1 R (EP672Y)
1 ml liquid Concentrated
Product Specifications
Designation
IVD
Reactivity
Paraffin
Visualization
Cytoplasmic
Control
Brain
Stability
Up to 36 mo. at 2-8°C
Isotype
IgG
Manual Protocol*
• Pretreatment: Heat Induced Epitope
Retrieval (HIER)
• Primary Antibody Incubation Time:
10-30min @ 25-37°C
• 2-step polymer detection
*Please refer to product insert for complete protocol.
Product Description
Anti-GFAP antibody detects astrocytes, Schwann cells, satellite cells, enteric glial cells, and some groups of ependymal cells. This marker is
mainly used to distinguish neoplasms of astrocytic origin from other neoplasms in the central nervous system.
Retroperitoneal Lesions
GFAP
NSE
Synapto-
physin
Chromo-
granin A
Neuro-
filament
PGP 9.5
S-100
CD99
Neuroblastoma
+/-
+
+
+
+
+
-
-
Ganglioneuroblastoma
+
+
+
+
+
+
+
-
Ganglioneuroma
+
+
+
+
+
+
+
-
Myoepithelial Tumor: Malignant vs. Benign
GFAP
CK
Cocktail
MS Actin Calponin SM
Myosin S-100
EMA CK 14
p63
Desmin
Malignant Myoepithelioma
+/-
+
+
+
+
+
+
+
-
-
Benign Myoepithelium
+
+
+
+
+
+
+
+
+
-
CNS Tumors
GFAP Neuro-
filament
Synapto-
physin S-100
CK
Cocktail
PR
EMA Vimentin NGFR INI-1
Astrocytoma
+
-
-
+
-
-
-
+
+
+
Glioblastoma
+
-
-
+
-
-
-
+
-
+
Oligodendriglioma
-
-
-
+
-
-
-
+
-
+
Ependymoma
+
-
-
+
-
-
-
-/+
+
+
Choroid Plexus Carcinoma
-/+
-
+
+
+
-
-
-
+
Central Neurocytoma
-
-
+
-
-
-
-
-
+
+
Neuroblastoma
+/-
+
+
+/-
-
-
-
+
+
+
Pineocytoma
-
-
+
-
-
-
-
-
+
Meningioma
-
-
-
-
-
+
+
+
-
+
Schwannoma
+
-
-
+
-
-
-
+
+
+
Rhabdoid Tumors
-
+/-
+/-
+
+
+
-
Metastatic Carcinoma
-
-
-
-
+
-/+
+
-/+
-
+
Reference
1. Viale G, et al. Virchow’s Arch A Pathol Anat. 1991; 418:339-348.
2. Choi BH, et al. Science. 1984; 223:407-409.
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