Advanced Solutions
for Advanced Pathology
Myelin Basic Protein (Polyclonal)
Rabbit Polyclonal Antibody
Cat. No. Description
Volume
45236 IMPATH Myelin Basic Protein RTU R (Poly)
50 Tests
44346 Myelin Basic Protein RTU R (Poly)
7 ml Ready To Use
44712 Myelin Basic Protein 0,1 R (Poly)
100 µl liquid Concentrated
44713 Myelin Basic Protein 1 R (Poly)
1 ml liquid Concentrated
Product Specifications
Designation
IVD
Reactivity
Paraffin
Visualization
Cytoplasmic
Control
Brain
Stability
Up to 36 mo. at 2-8°C
Manual Protocol*
• Pretreatment: Heat Induced Epitope
Retrieval (HIER)
• Primary Antibody Incubation Time:
10-30min @ 25-37°C
• 2-step polymer detection
*Please refer to product insert for complete protocol.
ImPath Protocol*
• Dewax: Dewax Solution 2 (DS2)
• Pretreatment: Retrieval Solution pH 9.0
(TR1) 32min @ 98-103°C
• Primary Antibody Incubation Time:
10-90min @ 25-37°C
• HRP Polymer (Universal) or AP Polymer
(Universal) for 12 min
*Please refer to product insert for complete protocol.
Product Description
Myelin basic protein (MBP) is a protein believed to be important in the process of myelination of nerves in the central nervous system (CNS).
MBP is present in the central and peripheral nervous system. The pool of MBP in the central nervous system is very diverse, with several splice
variants being expressed and a large number of post-translational modifications on the protein, which include phosphorylation, methylation,
deamidation and citrullination.
MBP has been demonstrated in neuromas, neurofibromas, and neurogenic sarcomas; other spindle cell neoplasms do not stain with this
antibody. Immunoreactivity for anti-MBP in granular cell tumors strengthens the concept of a Schwann cell derivation of these lesions. Unlike
other nervous system proteins, e.g. GFAP and S-100, MBP has not been demonstrated in melanocytes or tumors derived from them.
Neuroid Skin Lesions
Myelin BP
S-100
CD57
GFAP
Neuroma
+
+
+
-
Neurotised Nevi
-
+
-
-
Neurofibroma
+
+
+
-
Reference
1. Martenson RE, et al. J Neurochem. 1981; 36:1543-1560.
2. Uyemura K, et al. Adv Exp Med Biol. 1977; 100:95-11.
3. Buss A, et al. Brain. 2004 Jan; 127(Pt 1):34-44. Epub 2003 Oct 08.
4. Neuen-Jacob E, et al. Int J Legal Med. 1993; 105(6):339-50.
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