Antibodies for
Immunohistochemistry
MUM1 (MRQ-43)
Rabbit Monoclonal Antibody
Cat. No. Description
Volume
45234 IMPATH MUM1 RTU R (MRQ-43)
50 Tests
44344 MUM1 RTU R (MRQ-43)
7 ml Ready To Use
44708 MUM1 0,1 R (MRQ-43)
100 µl liquid Concentrated
44709 MUM1 1 R (MRQ-43)
1 ml liquid Concentrated
Product Specifications
Designation
IVD
Reactivity
Paraffin
Visualization
Cytoplasmic, Nuclear
Control
Diffuse large B-cell lymphoma,
Plasmacytoma, Tonsil
Stability
Up to 36 mo. at 2-8°C
Isotype
IgG
1
Manual Protocol*
• Pretreatment: Heat Induced Epitope
Retrieval (HIER)
• Primary Antibody Incubation Time:
10-30min @ 25-37°C
• 2-step polymer detection
*Please refer to product insert for complete protocol.
ImPath Protocol*
• Dewax: Dewax Solution 2 (DS2)
• Pretreatment: Retrieval Solution pH 9.0
(TR1) 32min @ 98-103°C
• Primary Antibody Incubation Time:
10-90min @ 25-37°C
• HRP Polymer (Universal) or AP Polymer
(Universal) for 12 min
*Please refer to product insert for complete protocol.
Product Description
MUM1 (multiple myeloma oncogene-1)/IRF4 (interferon regulatory factor 4) is a 50 kDa protein encoded by MUM1 gene, and a member of the
interferon regulatory factor family of transcription factors. MUM1/IRF4 is expressed in the nuclei of plasma cells and a small percentage of
germinal center (GC) B-cells located in the “light zone”. This antibody stains MUM1 protein, which is expressed in a subset of B-cells in the light
zone of the germinal center, plasma cells, activated T-cells, and a wide spectrum of related hematolymphoid neoplasms derived from these cells.
Therefore, this antibody is useful for the subclassification of lymphoid malignancies and an excellent marker for Reed-Sternberg cells of classic
Hodgkin disease in combination with anti-CD30.
B-cell Lymphomas
MUM1 CD20
CD5
BCL2
BCL6
TCL1
CD10
CD23 Cyclin D1 PU.1
Follicular
-
+
-
+
+
+
+
-
-
+
CLL/SLL
+
+
+
+
-
+
-
+
-
+
Mantle Cell
-/+
+
+
+
-
+
-
-
+
+
Marginal Zone
+
+
-
+
-
-
-
-
-
+
Lymphoplasmacytic
+
+
-
+
-
+
-
-
-
Diffuse Large Cell
+
+
-/+
+
+
+
-/+
-
-
+
Burkitt
-
+
-
-
+
+
+
-
-
Hodgkin vs. Non-Hodgkin Lymphomas
MUM1 CD79a CD15
CD30 Fascin Granzyme
B
BCL6
PU.1
ALK-1
EMA
Hodgkin Lymphoma,
Classic
+
-
+
+
+
-
-
-
-
-
Hodgkin Lymphoma,
Nodular Lymphocyte
Predominant
-/+
+
-
-
-
-
+
+
-
+
T-cell Rich LBCL
+
+
-
-
-
-
+
-
-
-
Anaplastic Large Cell
Lymphoma
-
-
-
+
-
+
+/-
-
+
+
Plasma Cells
MUM1
CD138
CD79a
EMA
CD56 Cyclin D1 CD43
CD20
CD19
Plasma Cell Neoplasm
+
+
+
+
+
-/+
-
-/+
-
Reference
1. Falini B, et al. Blood. 2000; 95:2084-92.
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