Antibodies for
Immunohistochemistry
Beta-Catenin (14)
Mouse Monoclonal Antibody
Cat. No. Description
Volume
44207 Beta-Catenin RTU M (14)
7 ml Ready To Use
44439 Beta-Catenin 0,1 M (14)
100 µl liquid Concentrated
44440 Beta-Catenin 1 M (14)
1 ml liquid Concentrated
Product Specifications
Designation
IVD
Reactivity
Paraffin
Visualization
Membranous, Nuclear
Control
Breast Carcinoma, Fibromatosis of
Breast
Stability
Up to 36 mo. at 2-8°C
Isotype
IgG
1
Manual Protocol*
• Pretreatment: Heat Induced Epitope
Retrieval (HIER)
• Primary Antibody Incubation Time:
10-30min @ 25-37°C
• 2-step polymer detection
*Please refer to product insert for complete protocol.
Product Description
Beta-catenin is a 92 kD protein normally found in the cytoplasm of the cell in the submembranous location. This protein is associated with
E-cadherin and may be essential for the function of E-cadherin. Mutations in the beta-catenin gene result in nuclear accumulation of this protein.
Nuclear accumulation of this protein has been demonstrated in fibromatosis lesions of the breast and abdomen and therefore is useful in
differentiating this lesion from other spindle cell lesions that may occur in these locations. Nuclear accumulation of beta-catenin has also been
demonstrated in colorectal carcinoma.
Breast Lesion
β-Catenin
GCDFP-15
Mammaglobin
E-cadherin
CK, 34βE12
p120
Lobular
-
+
+
-
+
+(cytoplasmic)
Ductal
+(membranous)
+
+
+
-
+(membranous)
Pancreatic Tumors
β-Catenin Synapto-
physin
Chromo-
granin A E-cadherin CD10 Gastrin MUC4 CD56
CK 19 CA19-9
Pancreatic
Adenocarcinoma
-
-
-
-
+/-
-
+
-
+
+
Neuroendocrine
+
+
+
-
-
+/-
-
+
+/-
+/-
Solid Pseudopapillary
+
+
-
-
+
-
+
-
-
Pancreatic Ductal
Carcinoma
+/-
-
-
+/-
+/-
-
-
-
+
Acinic Cell Carcinoma
+
-
-
+
+/-
-
-
+
-/+
Pancreatoblastoma
+
-
+
-
-
-
-
+
-
-
Benign Pancreas
+
+
+
-
-
-
-
-
-
-
Spindle Cell Tumors
β-Catenin
PGP 9.5
MS Actin
SM Actin
EMA
CK Cocktail
Calponin
Spindle Cell Carcinoma
+/-
+
-
-
+/-
+
-
Endometrial Stromal Tumor
+/-
+
+
+
-
-
+
Fibromatosis
+
+
-
+
-
-
-
Reference
1. Alman BA, et al. Am J Pathol. 1997 Aug; 151(2):329-34.
2. Li C, et al. Am J Pathol. 1998 Sep; 153(3):709-14.
3. Kuhnen C, et al. Pathol Res Pract. 2000; 196(5):299-304.
4. Abraham SC, et al. Hum Pathol. 2002 Jan; 33(1):39-46.
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