Antibodies for
Immunohistochemistry
Oct-2 (MRQ-2)
Mouse Monoclonal Antibody
Cat. No. Description
Volume
45160 IMPATH Oct-2 RTU M (MRQ-2)
50 Tests
44355 OCT-2 RTU M (MRQ-2)
7 ml Ready To Use
44730 OCT-2 0,1 M (MRQ-2)
100 µl liquid Concentrated
44731 OCT-2 1 M (MRQ-2)
1 ml liquid Concentrated
Product Specifications
Designation
IVD
Reactivity
Paraffin
Visualization
Nuclear
Control
Lymph Node, Tonsil
Stability
Up to 36 mo. at 2-8°C
Isotype
IgG
1
/k
Manual Protocol*
• Pretreatment: Heat Induced Epitope
Retrieval (HIER)
• Primary Antibody Incubation Time:
10-30min @ 25-37°C
• 2-step polymer detection
*Please refer to product insert for complete protocol.
ImPath Protocol*
• Dewax: Dewax Solution 2 (DS2)
• Pretreatment: Retrieval Solution pH 9.0
(TR1) 32min @ 98-103°C
• Primary Antibody Incubation Time:
10-90min @ 25-37°C
• HRP 2-step Polymer (Universal) or AP
2-step Polymer (Universal) for 12 min
*Please refer to product insert for complete protocol.
Product Description
Oct-2 is a transcription factor of the POU homeo-domain family that regulates B-cell-specific genes. It has been shown that this factor
participates in transcriptional regulation during T-cell activation. The following show high levels of Oct-2 expression: Germinal center B-cells,
mantle B-cells, monocytoid B-cells, and plasma cells. Various lymphomas are also positive for this marker including the following: B-chronic
lymphocytic leukemia, mantle cell lymphoma, follicular lymphoma, marginal zone lymphoma, plasmacytoma, Burkitt lymphoma, diffuse large
B-cell lymphoma, T-cell rich B-cell lymphoma, and nodular lymphocyte predominant Hodgkin lymphoma.
B-cell Lymphomas
Oct-2
CD20 CD79a
TCL1
BCL6
CD5
CD10
CD23 Cyclin D1 PU.1
Follicular
+
+
+
+
+
-
+
-
-
+
CLL/SLL
+
+
+
+
-
+
-
+
-
+
Mantle Cell
+
+
+
+
-
+
-
-
+
+
Marginal Zone
+
+
+
-
-
-
-
-
-
+
Diffuse Large Cell
+
+
+
+
+
-/+
-/+
-
-
+
Hodgkin vs. Non-Hodgkin Lymphomas
Oct-2 MUM1
EMA CD79a CD15
CD30 Fascin Granzyme
B
BCL6
PU.1
Hodgkin Lymphoma,
Classic
-
+
-
-
+
+
+
-
-
-
Hodgkin Lymphoma,
Lymphocyte Predominant
+
-/+
+
+
-
-
-
-
+
+
T-cell Rich BCL
+
+
-
+
-
-
-
-
+
-
Non-Hodgkin BCL
+
+
-
+
-
-
-
-
+
+
Acute Myeloid Leukemia
Oct-2
MPO CD68
CD34
CD43 Lysozyme BOB.1 CD74
CD45 CD138
Acute Myeloid, M0
-
-
-
+
+
+
-
+
+
+
Promyelocytic, M3
+
+
-
-
+
-
+
-
Myelomonocytic, M4
+
+
+
+
+
+
-
+
+
Monoblastic, M5
+
+
+
-/+
+
+
-
+
+
Reference
1. Browne P, et al. Am J Clin Pathol. 2003 Nov; 120(5):767-77.
2. García-Cosío M, et al. Mod Pathol. 2004 Dec; 17(12):1531-8.
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