Antibodies for
Immunohistochemistry
Ksp-cadherin (MRQ-33)
Mouse Monoclonal Antibody
Cat. No. Description
Volume
45315 IMPATH Ksp-cadherin RTU M (MRQ-33)
50 Tests
44325 KSP Cadherin RTU M (MRQ-33)
7 ml Ready To Use
44672 KSP Cadherin 0,1 M (MRQ-33)
100 µl liquid Concentrated
44673 KSP Cadherin 1 M (MRQ-33)
1 ml liquid Concentrated
Product Specifications
Designation
IVD
Reactivity
Paraffin
Visualization
Cytoplasmic, Membranous
Control
Kidney
Stability
Up to 36 mo. at 2-8°C
Isotype
IgG
1
Manual Protocol*
• Pretreatment: Heat Induced Epitope
Retrieval (HIER)
• Primary Antibody Incubation Time:
10-30min @ 25-37°C
• 2-step polymer detection
*Please refer to product insert for complete protocol.
ImPath Protocol*
• Dewax: Dewax Solution 2 (DS2)
• Pretreatment: Retrieval Solution pH 9.0
(TR1) 32min @ 98-103°C
• Primary Antibody Incubation Time:
10-90min @ 25-37°C
• HRP Polymer (Universal) or AP Polymer
(Universal) for 12 min
*Please refer to product insert for complete protocol.
Product Description
Kidney-specific cadherin (Ksp-cadherin or cadherin-16) is a kidney-specific member of the cadherin family of cell adhesion molecules. Within
the kidney, Ksp-cadherin is found exclusively in the basolateral membrane of renal tubular epithelial cells and collecting duct cells, and not in
glomeruli, renal interstitial cells, or blood vessels. Recent studies have shown that anti-Ksp-cadherin can be used to distinguish chromophobe
renal cell carcinoma from oncocytoma with a membranous staining pattern in 96% of chromophobe carcinomas, but in only 6% of oncocytomas.
However, other studies report anti-Ksp-cadherin positivity in 100% of chromophobe RCCs, and 95% of oncocytomas.
Kidney: Renal Epithelial Tumors
Ksp-cadherin RCC
CD10
PAX-2
Vimentin Parvalbumin CD117
Ep-CAM
Clear Cell RCC
-
+
+
+
+
-
-
-
Chromophobe RCC
+
-/+
-/+
+
-
+
+
+
Oncocytoma
+/-
-
+/-
+
-
+
+
-
Reference
1. Mazal PR, et al. Hum Pathol. 2005 Jan; 36(1):22-8.
2. Shen SS, et al. Mod Pathol. 2005 Jul; 18(7):933-40.
3. Thedieck C, et al. Br J Cancer. 2005 Jun 6; 92(11):2010-7.
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