Antibodies for
Immunohistochemistry
Inhibin, alpha (R1)
Mouse Monoclonal Antibody
Cat. No. Description
Volume
45221 IMPATH Inhibin alpha RTU M (R1)
50 Tests
44320 Inhibin (Alpha) RTU M (R1)
7 ml Ready To Use
44662 Inhibin (Alpha) 0,1 M (R1)
100 µl liquid Concentrated
44663 Inhibin (Alpha) 1 M (R1)
1 ml liquid Concentrated
Product Specifications
Designation
IVD
Reactivity
Paraffin
Visualization
Cytoplasmic
Control
Adrenal Cortex
Stability
Up to 36 mo. at 2-8°C
Isotype
IgG
2a
Manual Protocol*
• Pretreatment: Heat Induced Epitope
Retrieval (HIER)
• Primary Antibody Incubation Time:
10-30min @ 25-37°C
• 2-step polymer detection
*Please refer to product insert for complete protocol.
ImPath Protocol*
• Dewax: Dewax Solution 2 (DS2)
• Pretreatment: Retrieval Solution pH 9.0
(TR1) 32min @ 98-103°C
• Primary Antibody Incubation Time:
10-90min @ 25-37°C
• HRP Polymer (Universal) or AP Polymer
(Universal) for 12 min
*Please refer to product insert for complete protocol.
Product Description
Anti–inhibin alpha is an antibody against a peptide hormone which has demonstrated utility in the differentiation between adrenal cortical tumors
and renal cell carcinoma. Sex cord stromal tumors of the ovary as well as trophoblastc tumors also demonstrate cytoplasmic positivity with this
antibody. This antibody has been used to make the differential diagnosis of intrauterine vs. ectopic pregnancy in endometrial curettings.
Adrenal Tumors
Inhibin
Calretinin
MART-1
Synaptophysin Chromogranin A
CD56
Pheochromocytoma
-
-
-
+
+
+
Adrenocortical Carcinoma
+
+
+
-/+
-
+
Adrenocortical Adenoma
+
+
+
-/+
-
+
Germ Cell Tumors vs. Carcinoma
Inhibin Oct-4
AFP Vimentin EMA
hPL
CD30 Glypican-3 CD117 PLAP
Seminoma
-
+
-
+
-
-
-
-
+
+
Embryonal Carcinoma
-
+
-
-
-
-
+
-
-
+
Choriocarcinoma
-
-
-
-/+
+
+
-
+
-
+
Yolk Sac Tumor
-
-
+
-
-
-
-
+
-
+
Carcinoma
-
-
-
-
+
-
-
-
-
-
Hypercalcaemic Small Cell
Carcinoma
-
-
-
-
+
-
-
-
-
-
Sex Cord Stromal Tumors
Inhibin
Calretinin
CD99
CK 7
EMA
Vimentin
MART-1
Granulosa Cell Tumors
+
+
+
-
-
+
+
Sertoli-Leydig Cell Tumors
+
+
-/+
+
-
+
+
Gynandroblastoma
+
+
Gonadoblastomas
+
+
+
-
-
+
-
Reference
1. Arora DS, et al. J Pathol. 1997 Apr; 181(4):413-8.
2. Stewart CJ, et al. Histopathology. 1997 Jul; 31(1):67-74.
3. Yamashita K, et al. Am J Obstet Gynecol. 1997 Dec; 177(6):1450 –7.
4. McCluggage Wg, et al. Am J Surg Pathol. 1998 May; 22(5):615-9.
5. Kommoss F, et al. Mod Pathol. 1998 Jul; 11(7):656-64.
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